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Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 745-759 doi: 10.1007/s11684-021-0880-3

Abstract: Methylated DNA immunoprecipitation sequencing and real-time qPCR found that the DNA N6-methyladeninemodification levels of protein phosphatase 1 regulatory subunit 3A (PPP1R3A) and autophagy related 3The underlying mechanism may be related to the regulation of DNA N6-methyladenine modification of PPP1R3A

Keywords： resistance     non-alcoholic fatty liver disease     Chinese herbal medicine     randomized controlled trial     DNAN6-methyladenine modification    

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RNA m6A modification and its function in diseases

Jiyu Tong, Richard A. Flavell, Hua-Bing Li

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 481-489 doi: 10.1007/s11684-018-0654-8

Abstract:

N6-methyladenosine (m6A) is the most common post-transcriptional RNAmodification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modification could be installed by m6A “writers” composed of core catalyticThe function of m6A is executed by m6A “readers” that bind to m6A modification in in vitro cell lines, in

Keywords： RNA modification     m6A     immunity     cancer     epigenetics    

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DNA alkylation promoted by an electron-rich quinone methide intermediate

Chengyun Huang,Steven E. Rokita

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 213-221 doi: 10.1007/s11705-015-1541-3

Abstract: aminohexyloligonucleotide accelerates formation of its reversible self-adduct and alkylation of its complementary DNA

Keywords： quione methide     DNA alkylation     reversible covalent reaction     bioconjugation     target-directed modification    

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Cu-doped Bi/Bi2WO6 catalysts for efficient N2 fixation by photocatalysis

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1412-1422 doi: 10.1007/s11705-023-2312-1

Abstract: In this paper, Cu-doped Bi2WO6 was synthesized via a solvothermal method and appliedit in photocatalytic N2 immobilization.photocatalyst, indicating that the synthesized photocatalyst is actually Bi/Cu-Bi2WO6N2 fixation and may providemore information on the design and preparation of heteroatom-doped semiconductor photocatalysts for N<

Keywords： Bi2WO6     Cu doping     work function     photocatalytic N2 fixation     charge    

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Relationship between reactive oxygen species and sodium-selenite-induced DNA damage in HepG2 cells

ZOU Yunfeng, NIU Piye, GONG Zhiyong, YANG Jin, YUAN Jing, WU Tangchun, CHEN Xuemin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 327-332 doi: 10.1007/s11684-007-0063-x

Abstract: In this study, we investigated the relationship between ROS and the levels of DNA damage induced by seleniteThe levels of DNA damage in HepG2 increased in all cells treated with an increasing dose of seleniteN-acetylcysteine (NAC), a known antioxidant, increased cell viability and decreased ROS generation.Moreover, NAC effectively blocked DNA damage induced by selenite.These results revealed that ROS might play an important role in selenite-induced DNA damage that can

Keywords： NAC     N-acetylcysteine     DNA     fluorescence     relationship    

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Kinematic calibration of precise 6-DOF stewart platform-type positioning systems for radio telescope

HERNáNDEZ, Marco CECCARELLI, Carlos LóPEZ-CAJúN, Alejandro GARCíA

Frontiers of Mechanical Engineering 2013, Volume 8, Issue 3,   Pages 252-260 doi: 10.1007/s11465-013-0249-7

Abstract:

The pose accuracy of a parallel robot is a function of the mobile platform posture. Thus, there is no a single value of the robot’s accuracy. In this paper, two novel methods for estimating the accuracy of parallel robots are presented. In the first method, the pose accuracy estimation is calculated by considering the propagation of each error, i.e., error variations are considered as a function of the actuator’s stroke. In the second method, it is considered that each actuator has a constant error at any stroke. Both methods can predict pose accuracy of precise robots at design stages, and/or can reduce calibration time of existing robots. An example of a six degree-of-freedom parallel manipulator is included to show the application of the proposed methods.

Keywords： pose errors     error estimation     parallel robot     radio telescopes    

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Conserved Surface Polysaccharide Are Protective Against a Wide Range of Microbial Pathogens Producing β-1–6-Linked Poly-N-Acetylglucosamine (PNAG)

Xi Lu,Guoqing Li,Jing Pang,Xinyi Yang,Colette Cywes-Bentley,Xuefu You,Gerald B. Pier,

Engineering doi: 10.1016/j.eng.2023.09.012

Abstract: The β-1–6-linked poly-N-acetylglucosamine (PNAG) polymer is a conserved surface polysaccharide produced

Keywords： Poly-     N     -acetylglucosamine     Conjugate vaccine     Monoclonal antibody    

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Engineering DNA Materials for Sustainable Data Storage Using a DNA Movable-Type System Article

Zi-Yi Gong, Li-Fu Song, Guang-Sheng Pei, Yu-Fei Dong, Bing-Zhi Li, Ying-Jin Yuan

Engineering 2023, Volume 29, Issue 10,   Pages 130-136 doi: 10.1016/j.eng.2022.05.023

Abstract:

DNA molecules are green materials with great potential for high-density and long-term data storageHowever, the current data-writing process of DNA data storage via DNA synthesis suffers from high costsHere, we developed a DNA movable-type storage system that can utilize DNA fragments pre-produced by cellIn this system, these pre-generated DNA fragments, referred to herein as "DNA movable types,"the costly and environmentally hazardous process of de novo DNA synthesis.

Keywords： 合成生物学     DNA信息存储     DNA活字存储系统     经济性DNA数据存储    

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Synthesis of ［RMIm］PF6（R=P, B, C6）ionic liquid under microwave irradiation and research of its conductivity

He Yongfu

Strategic Study of CAE 2008, Volume 10, Issue 9,   Pages 92-95

Abstract: bromize([BMIm]Br), 1-propyl-3-methylimidazolium bromize([PMIm]Br), 1-hexyl-3-methylimidazolium bromize ([C6MImEach of them reacted separately with HPF6 for 4 hours at room temperature to get hydrophobic imidazoliumionic liquids:1-butyl-3-methyl-imidazolium hexafluorophosphate([BMIm]PF6) and 1-propyl-3-methyl-imidazoliumhexafluorophosphate([PMIm]PF6),1-Hexane-3-methyl-imidazolium hexafluorophosphate([C6MIm]PF6).

Keywords： ionic liquids     microwave irradiation     conductivity     [BMIm]PF6     [PMIm]PF6     [C6MIm]PF6    

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Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

Frontiers of Medicine doi: 10.1007/s11684-023-1044-4

Abstract: Considering that high levels of interleukin-6 (IL-6) have been detected in several highly pathogenicacute respiratory syndrome in 2002, the Middle East respiratory syndrome in 2012, and COVID-19, the IL-6Thus, we review the history of cytokine storm and the process of targeting IL-6 signaling to elucidate

Keywords： SARS-CoV-2     COVID-19     cytokine storm     interleukin-6     tocilizumab    

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The role of PARP1 in the DNA damage response and its application in tumor therapy

Zhifeng Wang, Fengli Wang, Tieshan Tang, Caixia Guo

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 156-164 doi: 10.1007/s11684-012-0197-3

Abstract: ADP-ribosyl)ation of many key proteins in vivo and thus plays important roles in multiple DNAThe present review will focus on recent progress on the role of PARP1 in the DNA damage response andresistance of BRCA-deficient tumors to PARP inhibitors is also briefly discussed from the perspective of DNA

Keywords： PARP1     synthetic lethality     PARP inhibitor     DNA repair     cancer     NHEJ    

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Sustainable functionalization and modification of materials via multicomponent reactions in water

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 9,   Pages 1318-1344 doi: 10.1007/s11705-022-2150-6

Abstract: ground providing essential design criteria to develop advanced tools for efficient functionalization and modificationTo date, there is no exclusive review to report the sustainable functionalization and modification ofkinds of multicomponent reactions in water and aqueous media as green methods for functionalization and modification

Keywords： materials     multicomponent reactions     modification     functionalization     water    

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FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 714-728 doi: 10.1007/s11684-022-0959-5

Abstract: squamous cell carcinoma (n = 75, P = 0.0054) and lung adenocarcinoma (n = 94, 6 interacts and colocalizes with mTOR and S6K, which are the key molecules of theFRMD6 markedly enhances the interaction between mTOR and S6K, subsequently increasing the levels of endogenouspS6K and downstream pS6 in lung cancer cells.Furthermore, knocking out FRMD6 inhibits the activation of the mTOR signaling pathway in Frmd6

Keywords： FRMD6     lung cancer     mTOR pathway    

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Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 179-187 doi: 10.1007/s11705-009-0268-4

Abstract: our understanding of the mechanism of activation of ATM and its signaling pathways, explore whether DNA

Keywords： ataxia-telangiectasia mutated (ATM)     cell cycle checkpoint     DNA damage     signalling transduction    

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An investigation on modification mechanism of CH

Qiang XIN, Shanghong HUANG

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 3,   Pages 293-300 doi: 10.1007/s11709-017-0403-0

Abstract: is used as cross linking agent, the concentrated sulfuric acid is used as catalyst, and the chemical modificationModification mechanism of low temperature coal is studied by Scanning Electron Microscopy and other analytical

Keywords： low temperature     coal tar pitch     modification     road performance    

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Title Author Date Type Operation

Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach

Journal Article

RNA m6A modification and its function in diseases

Jiyu Tong, Richard A. Flavell, Hua-Bing Li

Journal Article

DNA alkylation promoted by an electron-rich quinone methide intermediate

Chengyun Huang,Steven E. Rokita

Journal Article

Cu-doped Bi/Bi2WO6 catalysts for efficient N2 fixation by photocatalysis

Journal Article

Relationship between reactive oxygen species and sodium-selenite-induced DNA damage in HepG2 cells

ZOU Yunfeng, NIU Piye, GONG Zhiyong, YANG Jin, YUAN Jing, WU Tangchun, CHEN Xuemin

Journal Article

Kinematic calibration of precise 6-DOF stewart platform-type positioning systems for radio telescope

HERNáNDEZ, Marco CECCARELLI, Carlos LóPEZ-CAJúN, Alejandro GARCíA

Journal Article

Conserved Surface Polysaccharide Are Protective Against a Wide Range of Microbial Pathogens Producing β-1–6-Linked Poly-N-Acetylglucosamine (PNAG)

Xi Lu,Guoqing Li,Jing Pang,Xinyi Yang,Colette Cywes-Bentley,Xuefu You,Gerald B. Pier,

Journal Article

Engineering DNA Materials for Sustainable Data Storage Using a DNA Movable-Type System

Zi-Yi Gong, Li-Fu Song, Guang-Sheng Pei, Yu-Fei Dong, Bing-Zhi Li, Ying-Jin Yuan

Journal Article

Synthesis of ［RMIm］PF6（R=P, B, C6）ionic liquid under microwave irradiation and research of its conductivity

He Yongfu

Journal Article

Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

Journal Article

The role of PARP1 in the DNA damage response and its application in tumor therapy

Zhifeng Wang, Fengli Wang, Tieshan Tang, Caixia Guo

Journal Article

Sustainable functionalization and modification of materials via multicomponent reactions in water

Journal Article

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Journal Article

Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Journal Article

An investigation on modification mechanism of CH

Qiang XIN, Shanghong HUANG

Journal Article